Fri Sep 16 2022

83 articles - From Friday Sep 09 2022 to Friday Sep 16 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Development and Validation of the Summary Elixhauser Comorbidity Score for Use With ICD-10-CM-Coded Data Among Older Adults.

The S-Elixhauser comorbidity score is well calibrated and internally validated but its advantage over the AHRQ Elixhauser and Charlson summary scores is unclear. Primary funding source National Institute on Aging.

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Prevalence and Characteristics of Adrenal Tumors in an Unselected Screening Population : A Cross-Sectional Study.

The prevalence of adrenal tumors in the general adult screening population is 1.4%, and most of these tumors are nonfunctioning regardless of patient age. Cortisol and aldosterone secretion are the main causes of functional adenomas. Primary funding source National Key Research and Development Program of China and National Natural Science Foundation of China.

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Lancet

Adjuvant atezolizumab versus placebo for patients with renal cell carcinoma at increased risk of recurrence following resection (IMmotion010): a multicentre, randomised, double-blind, phase 3 trial.

These study results do not support adjuvant atezolizumab for treatment of renal cell carcinoma. Funding F Hoffmann-La Roche and Genentech, a member of the Roche group.

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Adjuvant nivolumab plus ipilimumab or nivolumab alone versus placebo in patients with resected stage IV melanoma with no evidence of disease (IMMUNED): final results of a randomised, double-blind, phase 2 trial.

The recurrence-free and overall survival benefit of nivolumab plus ipilimumab over placebo reinforces the change of practice already initiated for the treatment of patients with stage IV melanoma with no evidence of disease. Funding Bristol-Myers Squibb.

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Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma: a randomised, open label, phase 2 trial.

The combination of nivolumab and ipilimumab represents a new first-line and salvage therapeutic option for advanced Merkel cell carcinoma. Funding Bristol Myers Squibb Rare Population Malignancy Program.

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Metabolic, behavioural, and psychosocial risk factors and cardiovascular disease in women compared with men in 21 high-income, middle-income, and low-income countries: an analysis of the PURE study.

The similar associations of other risk factors with cardiovascular disease in women and men emphasise the importance of a similar strategy for the prevention of cardiovascular disease in men and women. Funding Funding sources are listed at the end of the Article.

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N Engl J Med

A Randomized Trial of Enteral Glutamine for Treatment of Burn Injuries.

In patients with severe burns, supplemental glutamine did not reduce the time to discharge alive from the hospital. (Funded by the U.S. Department of Defense and the Canadian Institutes of Health Research; RE-ENERGIZE ClinicalTrials.gov number, NCT00985205.).

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Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis.

In this randomized trial involving patients with acute pancreatitis, early aggressive fluid resuscitation resulted in a higher incidence of fluid overload without improvement in clinical outcomes. (Funded by Instituto de Salud Carlos III and others; WATERFALL ClinicalTrials.gov number, NCT04381169.).

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Lower versus Higher Glycemic Criteria for Diagnosis of Gestational Diabetes.

The use of lower glycemic criteria for the diagnosis of gestational diabetes did not result in a lower risk of a large-for-gestational-age infant than the use of higher glycemic criteria. (Funded by the Health Research Council of New Zealand and others; GEMS Australian New Zealand Clinical Trials Registry number, ACTRN12615000290594.).

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Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma.

Neoadjuvant therapy with cemiplimab was associated with a pathological complete response in a high percentage of patients with resectable cutaneous squamous-cell carcinoma. (Funded by Regeneron Pharmaceuticals and Sanofi; ClinicalTrials.gov number, NCT04154943.).

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Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19.

None of the three medications that were evaluated prevented the occurrence of hypoxemia, an emergency department visit, hospitalization, or death associated with Covid-19. (Funded by the Parsemus Foundation and others; COVID-OUT ClinicalTrials.gov number, NCT04510194.).

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Ann Intern Med

Deep Venous Thrombosis.

Many patients with VTE will have a chronic disease requiring long-term anticoagulation. Postthrombotic syndrome affects 25% to 40% of patients with DVT and significantly impacts function and quality of life.

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Get Out the Vote: A Framework to Mobilize Medical Professionals to Vote.

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Lancet

Acute respiratory distress syndrome in adults: diagnosis, outcomes, long-term sequelae, and management.

Guideline recommendations, evidence, and uncertainties in relation to ARDS management are discussed. The future of ARDS strives towards a precision medicine approach, and the framework of treatable traits in ARDS diagnosis and management is explored.

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Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes.

The heterogeneity of the clinical syndrome, along with its biology, physiology, and radiology, has increasingly been recognised and incorporated into identification of phenotypes. A precision-medicine approach that improves the identification of more homogeneous ARDS phenotypes should lead to an improved understanding of its pathophysiological mechanisms and how they differ from patient to patient.

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COPD: from an end-stage disease to lifelong lung health.

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Hepatocellular carcinoma.

However, the optimal sequencing of drugs remains to be defined, and predictive biomarkers are urgently needed to inform treatment selection. In this Seminar, we present an update on the causes, diagnosis, molecular classification, and treatment of hepatocellular carcinoma.

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Offline: The health of the Uyghur people is all of our concern.

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The Global Fund: replenishment and future-proofing.

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Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission.

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N Engl J Med

Audio Interview: Developing Mucosal Immunity to Covid-19.

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Audio Interview: Responding to Monkeypox.

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Drawing the Line on Glycemia in Pregnancy.

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Fluid Resuscitation in Acute Pancreatitis - Going over the WATERFALL.

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Neuromyelitis Optica Spectrum Disorder.

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Time to Stop Using Ineffective Covid-19 Drugs.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Ann Intern Med

Adrenal Incidentalomas: Insights Into Prevalence.

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Annals Graphic Medicine - First Code.

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Annals On Call - Diagnosis and Treatment of Monkeypox Proctitis.

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Current Clinical Challenges in the Prevention and Management of COVID-19.

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Effectiveness of a Fourth Dose of COVID-19 mRNA Vaccine Against Omicron Variant Among Elderly People in Singapore.

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Lancet

Adjuvant checkpoint blockade following complete local therapy for melanoma metastases.

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Behavioural risk factors and cardiovascular disease: are women at higher risk?

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Classification of COPD: fostering prevention and precision medicine in the Lancet Commission on COPD.

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Combined nivolumab and ipilimumab in non-resectable Merkel cell carcinoma.

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Daiana Stolz: transforming the agenda for lung health.

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Dinesh Palipana: clinician and leading disability rights advocate.

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Human monkeypox virus infection in an immunocompromised man: trial with tecovirimat.

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Identifying patients for adjuvant therapy after nephrectomy.

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Mark Dransfield: breathing new ideas into COPD.

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Pakistan floods: impact on food security and health systems.

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Shinzo Abe.

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Supporting transgender and gender diverse medical students.

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Worries grow about medically assisted dying in Canada.

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N Engl J Med

Case 25-2022: A 25-Year-Old Woman with Headache and Blurred Vision.

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Case 28-2022: A 59-Year-Old Man with Headache and Progressive Neurologic Dysfunction.

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Cholesterol Pericarditis.

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Closing the Public Health Ethics Gap.

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Finding a New Mantra.

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Gallbladder Volvulus.

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Giant Coronary-Artery Aneurysm.

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Management of Hyperglycemia in Hospitalized, Non-Critically Ill Adults.

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Protecting Pregnant People and Babies from the Health Effects of Climate Change.

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Letters&Replies

Letters to the editors and authors’ replies

Lancet

Ianalumab in Sjögren's syndrome: what can we learn from lupus trials?

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Ianalumab in Sjögren's syndrome: what can we learn from lupus trials? - Authors' reply.

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Misclassification bias in estimating clinical severity of SARS-CoV-2 variants - Authors' reply.

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Misclassification bias in estimating clinical severity of SARS-CoV-2 variants.

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Substantial misdiagnosis of severe malaria in African children.

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N Engl J Med

Albuterol-Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma.

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Albuterol-Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma. Reply.

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Anti-Spike Mucosal IgA Protection against SARS-CoV-2 Omicron Infection.

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Case 17-2022: A 17-Year-Old Boy with Chest Pain.

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Case 17-2022: A 17-Year-Old Boy with Chest Pain. Reply.

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Effectiveness and Durability of the BNT162b2 Vaccine against Omicron Sublineages in South Africa.

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Frostbite - Diagnosis and Therapy.

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Frostbite - Diagnosis and Therapy.

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Frostbite - Diagnosis and Therapy. Reply.

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Japanese Encephalitis in Australia - A Sentinel Case.

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Mantle-Cell Lymphoma.

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Mantle-Cell Lymphoma. Reply.

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Neutralization of SARS-CoV-2 Omicron BA.2.75 after mRNA-1273 Vaccination.

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Prevention of Anal Cancer.

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Prevention of Anal Cancer.

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Prevention of Anal Cancer.

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Prevention of Anal Cancer. Reply.

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Rapid Nanopore Sequencing-Based Screen for Aneuploidy in Reproductive Care.

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The Vaccine-Hesitant Moment.

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The Vaccine-Hesitant Moment. Reply.

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Treatment for Mild Chronic Hypertension during Pregnancy.

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Treatment for Mild Chronic Hypertension during Pregnancy.

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Treatment for Mild Chronic Hypertension during Pregnancy. Reply.

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Uncovered Medical Bills after Sexual Assault.

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Vaccine-Induced Immune Thrombocytopenia and Thrombosis after the Sputnik V Vaccine.

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